Grafting of 2-Hydroxypropyl-beta-Cyclodextrin on Gum Arabic-Modified Iron Oxide Nanoparticles as a Magnetic Carrier for Targeted Delivery of Hydrophobic Anticancer Drug

Volume 7 Issue 1, Pages 111 – 118

Shashwat S. Banerjee, Dong-Hwang Chen
Published Online: Dec 11 2008
12:10PM

DOI: 10.1111/j.1744-7402.2008.02332.x

ABSTRACT
A new magnetic nanocarrier for the targeted delivery of hydrophobic
drugs was developed by modifying magnetic nanoparticles with gum arabic
and grafting with 2-hydroxypropyl-cyclodextrins (HCD) using
hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic
diameter, and grafting of HCD were characterized. The resultant magnetic
nanocarrier exhibited an excellent capability to load
all-trans-retinoic acid (ATRA), an anticancer agent. The better
biocompatibility and the combined properties of specific targeting and
complexation ability with hydrophobic drugs make the nanosystem an
exciting prospect for targeted delivery of hydrophobic drugs.

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