GFMAT-2/BIO-4 Plenary Abstracts | The American Ceramic Society

GFMAT-2/BIO-4 Plenary Abstracts


From volta to solar impulse:  A battery journey

From 30 years, the development of lithium-ion batteries has considerably changed your life. The gain in specific energy has allowed the development of mobile devices which are now used by billions of people. Today, the new goals concern the development of Electrical Vehicle and the storage of renewable energy. This requires very high energy batteries, 104 to 105 larger than the smartphone ones. The battery life time, the material availability and the price are now the main parameters which need to be considered. For mobile applications lithium-ion batteries seem to remain the best ones, while for stationary applications Na-ion batteries are very promising thanks the Na availability and its low the price.

In this challenge the materials of tomorrow for the electrodes and the electrolyte have to be discovered and optimized. This presentation will give a general overview of the basics problems which have to be solved with a special focus on layered materials which seems now the most promising ones. Even if the batteries concern electrochemistry, the materials problems have to be considered from solid state chemistry. Now electrochemistry is a new tool for the solid state chemist. Several examples will be presented from this viewpoint.

Mrityunjay Singh, President of the World Academy of Ceramics, Italy and past president of ACers

Fourth industrial revolution and its impact on sustainable societal development

The dawn of the fourth industrial revolution has ushered in a new era in the development of advanced materials, cutting edge technologies, and innovative products, which are pervading every sphere of human activity and affecting our lives in many ways. While the discovery of new materials has been known to culminate in major turning points in human history, these developments have also started a new era in manufacturing and production leading to different industrial revolutions during the last century. The transformative impact and functional manifestation of new materials have been demonstrated in every historical era by their integration into new products and systems. The rapidly increasing global population and higher demand of products is leading to a dramatic increase in the consumption of resources and rate of pollution creating the risk of irreversible changes in the ecosystem. The fourth industrial revolution builds and extends the impact of digitization in new and unanticipated ways leading to more efficient production and resource utilization. It is crucial for global development and economic competitiveness providing innovative sustainable development solutions to address future societal needs. This presentation will cover wide ranging resource sustainability topics and identify key challenges and opportunities for various technologies including AI, machine learning, and big data in sustainable development.

Robert Pilliar, Professor emeritus, Faculty of Dentistry and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada

Porous calcium polyphosphates – Biodegradable bone substitutes and beyond

Porous biodegradable calcium polyphosphate (CPP) implants are being studied for use in repair of skeletal defects due to disease, trauma or congenital abnormalities. CPP degrades in vivo releasing Ca2+ and PO43- ions that, if released at an appropriate rate, can serve as bone defect substitutes either in particulate or porous bulk form. Porous bulk substitutes can be custom-made to desired form using a novel additive manufacture + post-AM annealing treatment to allow fabrication of precisely-formed implants for press-fitting into defect sites where they become fixed through bone ingrowth with gradual resorption of CPP resulting, in time, in defect repair through new bone regeneration. For repair of synovial joints involving degraded articular cartilage and subchondral bone, novel biphasic implants are made with articular cartilage, formed in vitro by cell culture methods, attached to porous CPP substrates. The biphasic implants can be fitted into defect sites and in time will result in repair as a result of new tissue (cartilage and bone) regeneration. This approach can be extended to whole joint regeneration of certain joints thereby potentially offering an alternative to current practice of joint replacement using metal, ceramic, polymer implant components. The novel biphasic CPP-cartilage implants offer the possibility of regeneration rather than replacement of degraded tissues.

Serena M. Best, Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge

Optimizing bioactive scaffolds: Cellular response to calcium phosphate composition and architecture

There have been a number of examples of successful translation of bioceramics research into clinical products over the past 40 years. In the field of orthopaedic surgery, the development of calcium phosphates has shown particular potential, due to their similarity with the chemical composition of bone mineral. Hydroxyapatite (Ca10(PO4)6(OH)2) has been of particular interest due to the ability to control composition by making chemical substitutions in the crystal lattice, which encourage bone repair.  It is understood that even small changes in elemental- and phase “impurity” content can influence the biological response to the implant. Going forward, the field of tissue engineering (in bone grafting, for example) relies on the supply of high quality three dimensional scaffolds and their architecture contributes significantly to performance, This presentation will review historic and recent developments to understand the control of physical and chemical characteristics of bioactive ceramics for optimised biological response.

Xingdong Zhang, Professor of National Engineering Research Center for Biomaterials, Sichuan University

Biofunctionalization—A New Direction for Bioceramics Research

Bioceramics have been used in clinic for a long time and achieved great success. However, traditional bioceramics, including nearly bioinert and bioactive ceramics, do not have the biological function of regulating cell behavior and differentiation, and thus cannot induce the regeneration of damaged tissues or organs or improve their biological function. With the progress in modern medicine, repair and replacement of tissue or organ has entered a new stage – to regenerate a living tissue or organ. Conventional wisdom believes that traditional bioceramics cannot meet this requirement, and only active biological substances can induce tissue regeneration.

However, we found and demonstrated in the 1990s that bioceramics could induce the regeneration or formation of damaged/injured bone tissue by optimizing their design without the addition of living cells or growth factors. Based on this research, an osteoinductive bioceramics has been developed and has been successfully used in approximately 300,000 clinical cases. Further studies have shown that a nano CaP bioceramics can selectively regulate apoptosis or proliferation of cells. When the bone tumor or melanoma cells were co-cultured with normal cells, such as osteoblasts and fibroblasts, in the medium with nano bioceramics, we found that the apoptosis of tumor cells but the proliferation of the normal cells. The findings suggest that bioceramics may have the potential to treat diseases such as tumors and osteoporosis. Animal and clinical trials have been conducted and are showing good results.

The report shows advances in the biofunctionalization of bioceramics, which may provide a revolutionary approach to regenerate tissue or organ by inanimate biomaterials.