SYMPOSIUM 32 – Mechanobiology and Cell-Substrate interactions at Biointerfaces in Bioceramics: Theory and Experiments

The unique properties and organized structures of bioceramics and bioceramic composites have resulted in their multitude of applications in biomedical engineering that include dental, hard and soft tissues, drug delivery, disease modeling, and wound healing, among others. In addition, the biological responses at the interfaces of these biomaterials with the biological world is a topic that is extensively investigated through experiments and modeling. This symposium will attempt to bring together experimentalists in the area of materials design of bioceramics and bioceramic composites for a variety of biomedical applications with modelers who bring a simulation-guided materials design as well as modelers and experimentalists who investigate cell-cell and cell-substrate interfaces. Novel experimental characterization of mechanics of cellular and tissue systems using AFM and nanoindentation based experimentation as well as biological, genetic, biomechanical and molecular characterization of biointerfaces will be covered. New advanced multiscale mothods in bioceramics design as well as molecular, cell and tissue level modeling of biointeraces will presented. Recent evaluations that use machine learning-based approaches to evaluate these interfaces will also be represented.

Session Topics:

Experimental evaluation of bio-nanointerfaces of bioceramic composites with substrates
Multiscale modeling of bioceramics and bioceramic composites
Novel characterization methods for evaluating mechanical behavior from nano to macro scale for bioceramics and bioceramic composites through experiments such as nanoindentation, biochemical characterization, spectroscopies, electron microscopy, etc.
Multiscale and molecular mechanics of interface proteins for evaluation of cell-cell and cell-substrate adhesions with bioceramics
Cellular and tissue mechanics on bioceramics and its role in disease
Bioceramics based human invitro disease models
Predictive modeling and machine learning on biodesign and evaluations
Advanced 3D manufacturing using bioceramics for biomedical applications

Symposium Organizer(s):

Kalpana S. Katti, North Dakota State University, USA
Hrishikesh Kamat, James R. Glidewell Dental Ceramic Incorporated, USA
Annabel Braem, KU Leuven, Belgium
Ashutosh Kumar Dubey, Indian Institute of Technology, India
Anamika Prasad, Florida International University, USA

Point(s) of Contact:

Kalpana S. Katti; Kalpana.Katti@ndsu.edu

Division Sponsor(s):

Bioceramics Division