Sergei Kalinin is a Weston Fulton Chair Professor at the University of Tennessee, Knoxville. In 2022-2023, he spent a year at Amazon (special projects) as a principal scientist, following 20 years at Oak Ridge National Laboratory (ORNL). He received his MS degree from Moscow State University in 1998 and Ph.D. from the University of Pennsylvania in 2002. Sergei has co-authored >650 publications, with a total citation of ~50,000 and an h-index of ~110. He is a fellow of MRS, APS, IoP, IEEE, Foresight Institute, and AVS; a recipient of the Blavatnik Award for Physical Sciences (2018), RMS medal for Scanning Probe Microscopy (2015), Presidential Early Career Award for Scientists and Engineers (PECASE) (2009); Burton medal of Microscopy Society of America (2010); 4 R&D100 Awards (2008, 2010, 2016, and 2018); and a number of other distinctions. Sergei got introduced to scanning probe microscopy at UPenn working with Dawn Bonnell. At ORNL, he built the SPM program at the Center for Nanophase Materials Sciences, pioneering several new SPM techniques and applications such as band excitation and G-Mode SPM, electrochemical strain microscopy, and big data SPM modes. When at ORNL, he was introduced to scanning transmission electron microscopy by Steve Pennycook. As the inaugural director for the ORNL Institute for Functional Imaging of Materials (IFIM, 2014-2019), he and his team worked on bridging physical and chemical imaging and artificial intelligence. For the last 15 years, his research focuses on the applications of machine learning and artificial intelligence in nanotechnology, direct electron beam atomic fabrication, and materials discovery via scanning transmission electron microscopy, as well as mesoscopic studies of electrochemical, ferroelectric, and transport phenomena via scanning probe microscopy.