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I got a chance to interview Muhammet Toprak at the recent ICACC’10 conference. Toprak is a researcher in the Multifunctional Materials Division of the KTH – Royal Institute of Technology in Stockholm. In this video, Toprak discusses his work as part of a cross-functional team that is working to assemble and test nanoparticle systems for biomedical applications. In particular, they have been working on the synthesis, characterization and in vitro compatability (with immune-competent cells) of tunable superparamagnetic Fe3O4–SiO2 core–shell nanoparticles.

In general, the systems Toprak is working on are similar to those that were discussed in last week’s video regarding drug-delivery systems. Toprak’s materials are conceived as being as being able to deliver a payload, but they are first working on using them to improve imaging of biological tissue sites. For example, he discusses how particles loaded with both magnetic materials (such as iron) and fluorescent dyes could help with imaging a specific tumor, first, before treatment, to plan a surgical approach, and second, during the surgery to indicate if and where residual tumor cells need to be removed.

8 minutes.