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Biomedical Materials 2016 Plenary Speakers

 

Make your plans to participate and hear these esteemed speakers and expert panels.

 

Friday, July 29  |  8:00-10:00 a.m.

 

Plenary Speaker  |  8:00-8:45 a.m.

Streicher_RobertRobert M. Streicher, faculty of Medicine and Surgery, Universita dell ́Insubria, Varese

 

Title: Periprosthetic joint infection: Is there a role for oxide ceramics in its prevention?

 

Abstract: The presence of an implant reduces 100’000x the bacteria concentration needed to induce infection [1], since bacteria are able to survive in periprosthetic environment adhering to the implant. Periprosthetic Joint Infection (PJI) is a rare, but devastating problem with a high risk of mortality [2]. It often requires multiple readmissions and invasive surgeries, where also the emotional health of the patient is compromised [3]. The PJI care costs are substantially more than that of a primary surgery, which with its increasingly higher incidence is causing an economic burden in United States [4]. PJI is, apart from other reasons, caused by antibiotic resistance bacteria biofilm, strongly resistant to common pharmaceutical treatment. One of the key factors in preventing PJI is to decrease bacterial adhesion affecting implants surface: this is a very complex process, influenced by materials features and close local environment. Oxide ceramics for arthroplasty with their chemico-physical surface properties may be able to favor protein adsorption. Such feature might be correlated with biofilm adhesion and growth. Oxide ceramic surfaces have shown in recent in-vitro [5] and ex-vivo [6] (i.e. by exploiting revised total hip arthroplasty components) studies to be less prone to be colonized by bacterial strains in comparison to metal and polymer surfaces. Furthermore, hip arthroplasty registries in their latest analyses are confirming the capability of oxide ceramic bearings to be beneficial in terms of reduced PJI incidence [7,8].

 

1) Song Z et al. Orthop Rev (Pavia). 2013 Jun 7; 5(2): e14

2) Shahi A et al. AAOS Meeting 2016 (Orlando, March 1st-5th, 2016), Poster P037

3) Berliner JL et al. Clin Orthop Relat Res. 2016 Mar 8. [Epub ahead of print]

4) Kurtz SM et al. J Bone Joint Surg Am Apr 2007, 89(4) 780-5

5) Porporati AA et al. ISTA 2015 Vienna Abstract Book (Vienna, Sept 30th-Oct3rd, 2015)

6) Trampuz A et al. ISTA 2015 Vienna Abstract Book (Vienna, Sept 30th-Oct3rd, 2015)

7) Falcioni S et al. 11th EHS Congress, Stockholm – Sweden, 9-11 October 2014 Hip Int 2014; 24 (5): 491

8) Graves SE et al. ISTA 2015 Vienna Abstract Book (Vienna, Sept 30th-Oct3rd, 2015)

 

Biography: Robert M. Streicher studied polymer science in Vienna, Austria. After holding positions in research and production in Austria and Italy, he joined Sulzer Medizinaltechnik in 1981. There, he held various research positions and introduced several new technologies. He received his Ph.D. degree in mechanical engineering with his thesis “Tribology of artificial joints,” in 1993. In 1996, he joined Stryker in the position of director strategic research. Since 2013 he is vice-president of scientific and clinical affairs at CeramTec GmbH. He has published more than 350 abstracts, papers, and book chapters and edited a book on tribology in arthroplasty. He teaches biomaterials and biomechanics at the Universities of Varese (“Insubria”, Italy) and Zurich (“ETHZ” Switzerland) and, among other positions, he served as secretary general and as president of the International Society of Technology in Arthroplasty (ISTA).

 

THEME: Additive Manufacturing

 

Plenary Speaker  |  8:45-9:25 a.m.

Prashant N. Kumta, Edward R. Weidlein chair professor, University of Pittsburgh

 

Title: 3-D printing of resorbable calcium phosphate cement scaffolds for bone regeneration – myth or reality?

 

Abstract: Bone fractures exceeding a critical size inexorably require bone replacement materials or bone grafts to successfully heal the bony defects in an acceptable time. Amongst the various synthetic bone grafts explored, calcium phosphate cements (CPCs) are clinically preferred due to the excellent handling and setting characteristics in addition to their chemical similarity to natural bone. However, it is extremely challenging within the operating room (OR) environment to create CPC based scaffolds in-situ, matching the arbitrary and complex 3-D anatomical shapes with hierarchical porous structures mimicking the macroscopic and the internal microstructure of bony tissues, while providing the temporary mechanical function and mass transport properties. These problems are obviated by 3-D printing of customized patient specific implants. This presentation describes 3-D printing of novel CPC scaffolds with predesigned architecture and macro-pores. The regenerative capabilities of these printed CPC constructs were tested in a rabbit critical sized ulnar model and the results show union of the defects and formation of new bone on the printed scaffolds with or without the addition of any exogenous growth factors such as BMP-2. Successful outcome was potentially attributed to nanostructured CPC rendering rapid resorption yielding high Ca2+ concentration in the bone regeneration environment while also contributing to differentiation of stem cell towards the osteoblastic lineage.

 

Biography: Prashant Kumta obtained his bachelor of technology with honors in metallurgical engineering from the Indian Institute of Technology, Bombay, India in 1984. This was followed by M.S. and Ph.D. degrees in materials science and engineering from the University of Arizona in 1987 and 1990, respectively. He joined the department of materials science and engineering at Carnegie Mellon University following his graduation in 1990 as an assistant professor and was promoted to full professor with tenure in 1999. He also held joint faculty appointment in the biomedical engineering department. He joined the University of Pittsburgh in 2007. Kumta is the author and co-author of more than 150 refereed journal publications and has given more than 200 conference presentations with more than 66 invited presentations. He was also the recipient of the research initiation award from the National Science Foundation in 1993 and has been continuously listed in Who’s Who in Science and Engineering, Who’s Who in America, Who’s Who in the World and Who’s Who in American Education since 1999. He was the founding organizer of the first symposium on “electrochemically active materials for energy storage and devices” for the annual meeting of the American Ceramic Society held in Indianapolis in 1995, and has been actively involved in its organization and execution to date. He is currently the editor-in-chief of Materials Science and Engineering: B, Advanced Functional Solid-State Materials, an international journal by Elsevier Publications.

 

Saturday, July 30  |  8:00-10:00 a.m.

 

THEME: The Role of Materials Science for Diabetes Care

 

Plenary Speaker  |  8:00-9:00 a.m.

Daniel G Anderson Headshot

Daniel G. Anderson, associate professor, Massachusetts Institute of Technology

 

Title: Combinatorial development of materials for islet transplantation

 

Abstract: The fibrotic reaction to implanted biomaterials is a fundamental challenge to the development of immuno-isolation devices.  Here we describe our work developing new biomaterials and devices for the purposes of enabling islet transplantation.  In particular we describe the development of a large library of synthetic hydrogel materials, and the characterization of their biocompatibility in vivo.  Data will be presented on the nature of the immune response to these and conventional biomaterials.  Several lead materials have been identified with significantly improved biocompatibility in rodents and primates.  When formulated into microcapsules these materials enable functional, long-term islet transplantation in immune competent, diabetic rodents.  

 

Biography: Daniel G. Anderson is the Samuel A. Goldblith professor of applied biology, associate professor, chemical engineering and Institute for Medical Engineering and Science, and member of the Koch Institute for Integrative Cancer Research at MIT. He received his PhD in molecular genetics from the University of California at Davis. At MIT, he pioneered the use of robotic methods for the development of smart biomaterials for drug delivery and medical devices. His work has led to the first methods rapid synthesis, formulation, analysis, and biological evaluation of large libraries of biomaterials for use in medical devices, cell therapy and drug delivery. In particular, the advanced drug delivery systems he has developed provide new methods for nanoparticulate drug delivery, non-viral gene therapy, siRNA delivery, and vaccines. His work has resulted in the publication of over 230 papers, patents and patent applications. These patents have led to a number of licenses to pharmaceutical, chemical and biotechnology companies, and a number of products that have been commercialized or are in clinical development.

 

Expert Panel Discussion  |   9:00-10:00 a.m.

Daniel G. Anderson, associate professor, Massachusetts Institute of Technology

Shawn Kelley, Medtronic

Roger Narayan, University of North Carolina, Chapel Hill

 

Saturday July 30  |  1:30-3:30 p.m.

 

THEME: The Role of Materials Science on Vascular and Cardiac Therapy

 

Plenary Speaker  |  1:30-2:30 p.m.

Wu, Ming H.Ming H. Wu, vice president of engineering, Edwards Lifesciences Corporation

 

Title: Transcatheter heart valve biomaterials

 

Abstract: Aortic stenosis is a life-threatening disease. The mortality rate for symptomatic patients with severe aortic stenosis can be as high as 50% in one year. Open-heart aortic valve replacement with extracorporeal cardiopulmonary circulation support has long been a gold standard for treating patients suffering from aortic valve stenosis and regurgitation. In the past decade, transcatheter aortic valve implantation (TAVI) has emerged as a less invasive technology for treating patients with severe aortic stenosis. Clinical evidences from the randomized controlled PARTNER trial demonstrated the benefit of TAVI as a life-saving technology for inoperable patients (cohort B). Based on the cohort A clinical outcome, TAVI is also an attractive alternative to surgery in patients with a high operative risk. With recent improved device designs towards smaller profiles, ease of use and additional features to minimize paravalvular leak, newer generation devices are now in clinical studies for considerations for treating intermediate and low surgical risk patients. Both self-expanding and balloon expandable designs are currently approved for clinical uses. Although the biomaterials used in both designs have good histories in surgical heart valves and vascular stents, specific challenges unique to the transcatheter heart valve design as well as opportunities in novel biomaterial solutions and improvements for future generation device designs will be reviewed and discussed

 

Biography: Ming H. Wu is vice president engineering at Edwards Lifesciences Corporation in Irvine, California, a leading company in heart valve and hemodynamic monitoring technologies, where he manages the advanced materials technology, Global CAD Engineering and Packaging Development Organizations. Before joining Edwards in 2006, Wu had more than twenty years of experience at Memry Corporation, a Nitinol materials and device development and manufacturing company in Bethel, Connecticut.  During his career at Memry, he held a variety of technical and senior level management positions including chief metallurgist, director of engineering, vice president general manager, and vice president technology.

 

Wu received his BS in materials science and engineering from National Tsinghua University, Taiwan, in 1977.  From 1980 to 1985, he went on to earn his Master and Ph.D. degrees in materials science and engineering from the University of Illinois at Urbana-Champaign.

 

Wu is a member of the American Society of Materials (ASM) International, the ASM Shape Memory and Superelastic Technologies Society (SMST) and the American Society for Testing and Materials (ASTM). In addition to these affiliations, he served as a board member of the SMST Society and was a member and chair in the ASM MPMD strategic committee. Wu is currently an editorial board member for the Journal of Shape Memory and Superelasticity. He also participated in the external advisory boards for the materials science and engineering programs at the University of California at Los Angeles (UCLA) and the Fairfield University at Fairfield, Connecticut. 

 

Wu has more than 60 publications in scientific journals and conference proceedings as well as numerous pending and issued patents.

 

 

Expert Panel Discussion  |   2:30-3:30 p.m.

Ming H. Wu, vice president of engineering, Edwards Lifesciences Corporation

Jeremy Schaffer, Fort Wayne Metals Research Products Corporation

Narendra Vyavahare, Clemson University

 

Sunday, July 31  |  8:00-9:00 a.m.

 

THEME: The Role of Material Science in Orthopedics

 

Plenary Speaker  |  8:00-9:00 a.m.

Joshua J. Jacobs, Hip and knee replacement orthopedic surgeon, Midwest orthopaedics, Rush University Medical Center

 

Title: Tribocorrosion of orthopaedic implants: current concepts and clinical ramifications

 

Abstract: Corrosion at metal/metal modular interfaces in total hip arthroplasty was first described in the early 1990’s [1], and the susceptibility of modular tapers to mechanically assisted crevice corrosion (MACC), a combination of fretting and crevice corrosion, was subsequently introduced [2]. Since that time, there have been numerous reports of corrosion at this taper interface, documented primarily in retrieval studies or in rare cases of catastrophic failure.

 

We have reported that fretting corrosion at the modular taper may produce soluble and particulate debris that can migrate locally or systemically [3],  and more recently reported that this process can cause an adverse local tissue reaction [4,5]. Based on the type of tissue reaction and the presence of elevated serum metal ion levels, this process appears quite similar to adverse local tissue reactions secondary to metal on metal bearing surfaces [6]. While modularity in THR has demonstrable clinical benefits, modular junctions increase the risk of corrosion and the types of adverse soft tissue reactions seen in patients with accelerated metal release from metal-on-metal bearing THRs.

  1. Corrosion at the Interface of Cobalt-Alloy Heads on Titanium-Alloy Stems. Collier, J.P., V.A. Surprenant, R.E. Jensen, and M.B. Mayor, Clinical Orthopaedics and Related Research, 1991(271): p. 305-312.
  2. In-Vivo Corrosion of Modular Hip-Prosthesis Components in Mixed and Similar Metal Combinations – the Effect of Crevice, Stress, Motion, and Alloy Coupling. Gilbert, J.L., C.A. Buckley, and J.J. Jacobs, Journal of Biomedical Materials Research, 1993. 27(12): p. 1533-1544.
  3. Migration of Corrosion Products from Modular Hip Prostheses – Particle Microanalysis and Histopathological Findings. Urban, R.M., J.J. Jacobs, J.L. Gilbert, and J.O. Galante, Journal of Bone and Joint Surgery-American Volume, 1994. 76A(9): p. 1345-1359.
  4. Corrosion at the Head-Neck Taper as a Cause for Adverse Local Tissue Reactions After Total Hip Arthroplasty. John Cooper, H., C.J. Della Valle, R.A. Berger, M. Tetreault, W.G. Paprosky, S.M. Sporer, and J.J. Jacobs, The Journal of Bone & Joint Surgery, 2012. 94(18): p. 1655-1661.
  5. Adverse Local Tissue Reactions Arising from Corrosion at the Neck-Body Junction in a Dual Taper Stem with a CoCr Modular Neck. Cooper, H.J., R.M. Urban, R.L. Wixson, R.M. Meneghini, and J.J. Jacobs, The Journal of Bone & Joint Surgery, 2013. 95:865-872.
  6. Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement A CONSEQUENCE OF EXCESS WEAR. Langton, D.J., S.S. Jameson, T.J. Joyce, N.J. Hallab, S. Natu, and A.V.F. Nargol, Journal of Bone and Joint Surgery-British Volume, 2010. 92B(1): p. 38-46.

Biography: Joshua J. Jacobs, M.D. received a BS in Materials Science and Engineering from Northwestern University and an MD from the University of Illinois Medical School. He completed his orthopaedic residency at the Combined Harvard Orthopaedic Residency Program and a fellowship in Adult Reconstructive Orthopaedic Surgery at Rush.

 

Dr. Jacobs is the William A. Hark, M.D./Susanne G. Swift Professor and Chairman of the Department of Orthopaedic Surgery and the Associate Provost for Research at Rush University. Dr. Jacobs’ research focuses on the biological consequences of material degradation from joint replacement implants. He has received several research awards including the Kappa Delta Award of the AAOS. He is Past President of the ORS and the AAOS.

 

Expert Panel Discussion  |   9:00-10:00 a.m.

Joshua Jacobs, Rush University Medical Center

Robert M. Streicher, faculty of Medicine and Surgery, Universita dell ́Insubria, Varese

Bryan McEntire, Amedica Corp.

Helen Reveron, University of Lyon

Giorgio Perino, Hospital for Special Surgery

Christina Esposito, Hospital for Special Surgery

Caryn Etkin, AJRR

 


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